Neurological sequelae in newborn babies after perinatal asphyxia.

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Neurological sequelae in newborn babies after perinatal asphyxia.

A total of 53 babies, 37 to 44 weeks' gestational age with a history of fetal distress in labour, and severe neurological abnormalities in the early newborn period, were followed up for between 2 and 5 years. Their progress was compared with an equal number of normal babies matched for gestational age, birthweight, sex, and social class, but without a history of fetal distress or delay in estab...

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Neurological outcome after perinatal asphyxia at term

Introduction It was nearly 150 years ago that an association between perinatal events and brain injury was first reported, claiming that “the act of birth does occasionally imprint upon the nervous and muscular systems of the infantile organism very serious and peculiar evils” [1]. While a great deal is now known about this association and the pathophysiology behind it, the quantification of th...

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Neurological Complications of Perinatal Asphyxia

The degree of asphyxia is best ascertained by measuring the amount of fetal acidosis determined by umbilical arterial blood. An umbilical arterial pH of less than 7.0 is seen in about 0.3% of deliveries.1 It indicates a severity of acidosis that places the fetus at risk for permanent neurological damage because of asphyxia. However, the outcome of infants with umbilical cord pH of less than 7.0...

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Perinatal asphyxia in the term newborn

Despite the important advances in perinatal care in the past decades, asphyxia remains a severe condition leading to significant mortality and morbidity. Perinatal asphyxia has an incidence of 1 to 6 per 1,000 live full-term births, and represents the third most common cause of neonatal death (23%) after preterm birth (28%) and severe infections (26%). Many preconceptional, antepartum and intra...

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Mitochondrial function after asphyxia in newborn lambs.

We examined mitochondrial oxidative function 5 minutes and 2 hours after a gradual asphyxial insult in newborn lambs. We subjected 16 ventilated newborn lambs to 75-90 minutes of hypoxia and hypercarbia that resulted in bradycardia and systemic hypotension over the final 15 minutes of the insult. At the end of asphyxia, the lambs were resuscitated and returned to control ventilator settings. Sa...

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ژورنال

عنوان ژورنال: Archives of Disease in Childhood

سال: 1978

ISSN: 0003-9888,1468-2044

DOI: 10.1136/adc.53.7.564